comparing the effects of ginger and glibenclamide on dihydroxybenzoic metabolites produced in stz-induced diabetic rats

Authors

ramesh ahmadi department of physiology, islamic azad university, qom, ir iran; islamic azad university of qom, 15 khordad st, qom, ir iran. tel:+98-2537780001, fax:+98-2137770001

saeede pishghadam islamic azad university, qom, ir iran

fatemeh mollaamine department of chemistry, islamic azad university, qom, ir iran

mohammad reza zand monfared department of chemistry, islamic azad university, qom, ir iran

abstract

background the aim of the present study was to investigate the effect of ginger and glibenclamide on oxidative stress markers. oxidative stress is caused by an unbalance between a relative overload of oxidants and depletion of antioxidants, as implicated in the pathogenesis of several chronic diseases, including atherosclerosis and diabetes mellitus. regarding the role of oxidative stress in the pathogenesis of diabetes mellitus, we investigated the effect of ginger and glibenclamide in diabetic rats induced bystreptozocin (stz). objectives this study assessed the effects of ginger and glibenclamide on dihydroxybenzoic acid metabolites in diabetic rats. materials and methods in this study 30 wistar strain male rats were divided into five groups: group 1: normal control receiving normal saline (0.9 0/0), group 2: control dmso (dimethyl sulfoxide) (as solvent of glibenclamide), group 3: diabetic control receiving streptozocin (stz ) (50 mg/kg) ,group 4: diabetic+ ginger extract: this group received ginger ethanolic extract (200 mg/kg) via ip (intraperitoneally) injection for 30 days, and group 5 diabetic rats received glibenclamide (0.5 m/kg). production of hydroxyl radicals was examined in the diabetic rats induced by streptozocin. hydroxyl radicals were generated in plasma of the hyperglycemic rats, and were quantitatively assayed by trapping hydroxyl radicals with salicylic acid so as to produce 2,3-and 2,5-dihydroxybenzoic acid. results production of hydroxyl radicals increased; therefore, by using salicylic acid, hydroxyl radicals were trapped and 2,3dihydroxybenzoic acid and 2,5dihydroxybenzoic acid metabolites were formed then measured by hplc and spectrophotometer. rats receiving ginger extract and glibenclamide showed decreased level of metabolites compared to the diabetic controls (p <0/001). this means that antioxidants act as scavenger of free radicals. conclusions comparative effect of ginger and glibenclamide also showed that glibenclamide has antioxidant effect as a scavenger of free radical, but ginger is more capable of eliminating them.

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Comparing the Effects of Ginger and Glibenclamide on Dihydroxybenzoic Metabolites Produced in Stz-Induced Diabetic Rats

BACKGROUND The aim of the present study was to investigate the effect of ginger and glibenclamide on oxidative stress markers. Oxidative stress is caused by an unbalance between a relative overload of oxidants and depletion of antioxidants, as implicated in the pathogenesis of several chronic diseases, including atherosclerosis and diabetes mellitus. Regarding the role of oxidative stress in th...

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Cooregendium: Comparing the Effects of Ginger and Glibenclamide on Dihydroxybenzoic Metabolites Produced in Stz-Induced Diabetic Rats [published Int J Endocrinol Metab. 2013;11(4):e10266]

1Department of Physiology, Qom Branch, Islamic Azad University, Qom, IR Iran 2Department Of Biology, Qom branch, Islamic Azad University, Qom, IR Iran 3Department of chemistry, Qom branch, Islamic Azad university, Qom, IR Iran *Corresponding author: Ramesh Ahmadi, Department of chemistry, Qom branch, Islamic Azad university of Qom, 15 Khordad St, Qom, IR Iran. Tel:+98-2537780001, Fax:+982137770...

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Journal title:
international journal of endocrinology and metabolism

جلد ۱۱، شماره ۴، صفحات ۰-۰

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